The Rare Diseases: Models & Mechanisms Network (RDMM) has been established in Canada to catalyze connections between people discovering new genes in patients with rare diseases, and basic scientists who can analyze equivalent genes and pathways in model organisms.


MARRVEL(Model organism Aggregated Resources for Rare Variant ExpLoration) allows users to search multiple human and model organism databases simultaneously and provides a unified interface to facilitate the search process.


The Undiagnosed Diseases Network (UDN) in the United States of America is a research study backed by the National Institutes of Health Common Fund that seeks to provide answers for patients and families affected by mysterious medical conditions.


The Australian Functional Genomics Network (AFGN) will expedite the matchmaking of clinicians, diagnostic labs and researchers through the use of the Australian Functional Genomics Registry, a database of model system teams in Australian.


RDMM-Europe has been established by Solve-RD, an EU-funded research project including 22 beneficiaries and >20 associated partners. The overall aim is to boost research in rare diseases, discover new disease-causing genes and obtain evidence for pathogenicity through functional validation.


The Japanese RDMM (J-RDMM) is aiming to identify biological mechanisms of rare diseases under tight interaction between IRUD (Japan’s Initiative on Rare and Undiagnosed Diseases) researchers and model organism researchers.


GeneMatcher is a freely accessible web site designed to enable connections between clinicians and researchers from around the world who share an interest in the same gene or genes, developed by the Baylor-Hopkins Center for Mendelian Genomics.


PhenomeCentral is a repository for secure data sharing in the rare disease community which serves as the data repository for a number of national and international rare disease consortia.


MyGene2 is a portal through which families with rare genetic conditions who are interested in sharing their health and genetic information can connect with other families, clinicians, and researchers, developed by the University of Washington Center for Mendelian Genomics.

Matchmaker Exchange

The 'Matchmaker Exchange' project was launched in October 2013 to address this challenge and find genetic causes for patients with rare disease. This involves a large and growing number of teams and projects working towards a federated platform (Exchange) to facilitate the matching of cases with similar phenotypic and genotypic profiles (matchmaking) through standardized application programming interfaces (APIs) and procedural conventions.

Alliance of Genome Resources

The Alliance of Genome Resources develops and maintains a unified database that allows users to search across multiple model organism databases by implementing a shared, modular information system architecture.

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